tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate

tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate - Names and Identifiers

Name	tert-butyl 4-(3-bromophenyl)piperidine-1-carboxylate
Synonyms	4-(3-Bromo-phenyl)-piperidine-1- 1-Boc-4-(3-Bromophenyl)piperidine 3-(N-Boc-piperidin-4-yl)bromobenzene 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate tert-butyl 4-(3-bromophenyl)piperidine-1-carboxylate 4-(3-Bromophenyl)-1-piperidinecarboxylic acid tert-butyl ester 4-(3-Bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 1-Piperidinecarboxylic acid, 4-(3-bromophenyl)-, 1,1-dimethylethyl ester
CAS	886362-62-5
InChI	InChI=1/C16H22BrNO2/c1-16(2,3)20-15(19)18-9-7-12(8-10-18)13-5-4-6-14(17)11-13/h4-6,11-12H,7-10H2,1-3H3

tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C16H22BrNO2
Molar Mass	340.26
Density	1.283
Boling Point	397.8±42.0 °C(Predicted)
Flash Point	194.4°C
Vapor Presure	1.55E-06mmHg at 25°C
pKa	-1.69±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.543

tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate - Introduction

tert-butyl 4-(3-bromophene) piperidine-1-carboxylate is an organic compound with the chemical name tert-butyl 4-(3-bromophene) piperidine-1-carboxylate. Its properties include physical properties and chemical properties.

Physical Properties:
Appearance: colorless to light yellow crystal
Melting point: about 64-66°C
Molecular weight: 344.34g/mol

Chemical Properties:
tert-butyl 4-(3-bromophenyl)piperidine-1-carboxylate is an ester compound containing a piperidine ring and a bromophenyl group. It has good solubility and is soluble in common organic solvents such as chloroform, methanol and dichloromethane.

Use:
tert-butyl 4-(3-bromophenyl)piperidine-1-carboxylate has a wide range of applications in organic synthesis. It is often used as an intermediate in the synthesis of other compounds, such as drug candidates and bioactive molecules in the pharmaceutical field. In addition, it can also be used as a blocking agent, reducing agent and catalyst in organic synthesis reactions.

Preparation Method:
The preparation of tert-butyl 4-(3-bromophenyl)piperidine-1-carboxylate is generally obtained by reacting bromobenzene with N-Boc-4-piperidinol. The reaction is catalyzed using a base, is typically carried out under an inert atmosphere, and is carried out at low temperatures.

Safety Information:
tert-butyl the safety of 4-(3-bromophenyl)piperidine-1-carboxylate is relatively high, any chemical substance should be used under safe operation. When in use, should wear appropriate protective measures, such as laboratory gloves, protective glasses and laboratory clothing. At the same time, it is necessary to prevent contact with skin and eyes, and thoroughly wash and clean the experimental equipment after operation.

Last Update：2024-04-09 21:11:58